Pylorospasm or hypertrophic gastritis (associated vomiting and/or diarrhea)
Used for vomiting secondary to vestibular disease
Precautions and Side Effects
While generally safe and effective when prescribed by a veterinarian, aminopentamide (Centrine®) can cause side effects in some animals.
Aminopentamide should not be used in animals with known hypersensitivity or allergy to this drug or other anticholinergic medication.
It should not be used in patients with glaucoma because of accompanying mydriasis, which will occlude the filtration angle.
In addition, it should be avoided in patients with tachycardia secondary to cardiac conditions, shock, or thyrotoxicosis.
Other contraindications include: gastrointestinal obstruction, ileus, ulcerative colitis, urinary obstruction, and myasthenia gravis.
Aminopentamide may cause difficulties in visual accommodation and dryness of the mouth and conjunctivae. It may also cause urinary retention and dysuria.
Drug Interactions with Centrine®
No direct references to drug interactions are documented at this time. Consult with your veterinarian to determine if other drugs your pet is receiving could interact with Aminopentamide.
How Aminopentamide is Supplied
Aminopentamide is available as Centrine® in 0.2 mg tablets.
The injectable form is available as a 0.5 mg/mL concentration.
Dosing Information of Aminopentamide for Dogs and Cats
Medication should never be administered without first consulting your veterinarian.
Doses of aminopentamide vary widely in dogs and cats depending on the reason for prescribing. Dosages may be gradually increased above the suggested dose.
The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Be certain to complete the prescription unless specifically directed by your veterinarian. Even if your pet feels better, the entire treatment plan should be completed to prevent relapse.
The ususal dose, as per Centrine® Monograph (Fort Dodge) is as follows for dogs and cats: - Animals 10 pounds or less should receive 0.1 mg every 8 to 12 hours - Animals 11 – 20 pounds should receive 0.2 mg every 8 to 12 hours - Animals 21 – 50 pounds should receive 0.3 mg every 8 to 12 hours - Animals 51 – 100 pounds should receive 0.4 mg every 8 to 12 hours - Animals over 100 pounds should receive 0.5 mg every 8 to 12 hours